The time for IgA Nephropathy urine protein conversion should be assessed according to the severity of the patient’s condition as well as the treatment effect, etc. It is not possible to make a generalization. IgA nephropathy has an insidious onset, often manifested as asymptomatic hematuria, with or without proteinuria, often found during physical examination. Some patients often have precursor symptoms such as upper respiratory tract or gastrointestinal tract infections a few hours or days before the onset of the disease, which are mainly manifested as episodic hematuria, which can last for a few hours or days, and the hematuria is often painless, which can be accompanied by proteinuria, and is mostly seen in children and young people. IgA nephropathy usually requires the application of sartans, purgatives, and if necessary, drugs such as glucocorticoids or immunosuppressants to reduce urinary protein. If the patient’s condition is mild and the treatment is effective, the patient may experience a reduction in urine protein within a few weeks, and the exact time of conversion varies from person to person, and it is usually not possible to determine a fixed time. For some patients with severe disease or poor response to medication, the urine protein may not turn negative, and the kidney function may gradually deteriorate, eventually progressing to uremia. Patients with IgA nephropathy are advised to go to regular hospitals for timely consultation and standardized treatment under the guidance of doctors.