Uneasy stomach in the middle of the night is commonly caused by indigestion, duodenal ulcer and other diseases. Symptoms can be relieved by massaging the stomach, drinking more hot water, and taking oral omeprazole or gastrointestinal tablets. Many patients have stomach discomfort in the middle of the night due to eating more food at night. It is recommended to take oral medication such as gastrointestinal tablets under the guidance of a doctor. It is recommended not to eat too much at each meal to avoid a heavier load on the stomach. You can reduce the workload of the gastrointestinal tract by eating fewer and more frequent meals. Duodenal ulcer can also appear in the middle of the night abdominal pain and other symptoms, can follow the doctor’s instructions to take omeprazole, aluminum sulfate and other drugs for treatment. Some patients due to the cold abdomen during the night sleep, it is recommended to drink more warm water to replenish the water in the body, which can help defecation. But be careful not to drink carbonated drinks to avoid aggravating the symptoms of abdominal pain. The stomach discomfort in the middle of the night may be caused by flatulence, which can be improved by massaging the stomach, such as clockwise massage of the abdomen, which can effectively relieve the symptoms of flatulence. It is recommended that patients go to the hospital as soon as possible to do a careful examination, such as ultrasound testing, physical examination, health examination, etc., to clarify the cause of the disease, and symptomatic treatment under the guidance of the doctor.