There are many reasons for feeling vague pain in the liver, which may be caused by non-disease factors, such as emotional disorders, overwork, or caused by diseases, such as hepatitis, fatty liver, cholecystitis, intercostal neuralgia and so on. 1. Non-disease factors (1) Emotional disorders: some people are irritable and agitated, which may cause vague pain in the liver area. (2) Overwork: Because the liver has a metabolic function, when overwork, the body’s energy supply is insufficient, which may induce transaminase increase, which is a transient increase, and the patient may also have vague pain in the liver area. 2. Diseases (1) Hepatitis: it is a common cause of vague pain in the liver area, because there is a translucent hepatic peritoneum on the outside of the liver, which is rich in sensory nerve endings. Hepatitis causes different degrees of inflammatory swelling of the liver, which can stimulate the nerves and cause pain. (2) Fatty liver: The liver is infiltrated by fatty tissue, resulting in enlargement, which makes the hepatic peritoneum overstretched and stimulates the sensory nerves on it. (3) Cholecystitis: gallbladder lesions can also cause vague pain in the liver area, such as cholecystitis and gallstones. (4) Intercostal neuralgia: the pain is distributed in a semi-circumferential shape and can radiate to the liver area, which should be distinguished from vague pain in the liver area. When the patient feels that the vague pain in the liver persists without relief, he should consult a doctor in time to clarify the cause of the disease and then actively treat it.