Wandering pain in appendicitis, left to right abdomen, is due to the fact that the appendix belongs to the visceral innervation and is inaccurately localized in response to painful stimuli. The appendix is located in the ileocecal region of the right lower abdomen, with the root connecting to the cecum while the distal end is free, and can extend to any direction in the abdominal cavity with changes in position. The appendix is mainly innervated by the sympathetic nerves and small visceral nerves emanating from the 10th and 11th spinal cord. After infection and other factors cause inflammatory lesions such as edema and exudation of the appendix, the stimulus response to pain is inaccurate and there is a drawing pain in the periumbilical region, which is innervated by the 10th and 11th segments of the spinal cord. As the inflammation gradually intensifies, the irritation becomes clearer, so that it is again concentrated in the right lower abdomen. Typical signs of appendicitis are pressure and rebound pain in the middle and outer 1/3 of the line between the umbilicus and the right anterior superior iliac spine, and common symptoms include nausea, vomiting, fever, and chills.