Erythromycin is commonly used in the form of tablets, ointment and eye ointment, which cannot eradicate nasal polyps. Erythromycin is a macrolide antibiotic, erythromycin enteric-coated tablets are used for the treatment of acute tonsillitis, acute pharyngitis, sinusitis, scarlet fever due to hemolytic streptococcus, cellulitis, Mycoplasma pneumoniae pneumonia and other conditions. Erythromycin ointment is used for the treatment of purulent skin diseases and small burns, ulcer surface infection. Erythromycin ophthalmic ointment is used for the treatment of trachoma, conjunctivitis, blepharitis, and infections external to the eye. Glucocorticoid nasal sprays such as tretinoin and budesonide can be used clinically as prescribed to treat nasal polyps. If the symptoms are not relieved, the nasal polyps can also be removed by surgery as prescribed by the doctor, and the commonly used surgeries are nasal endoscopic resection and traditional nasal polypectomy. Nasal polyps combined with purulent sinusitis can be treated with erythromycin, but erythromycin can not eradicate nasal polyps, it is recommended that the patient in the doctor’s guidance and reasonable treatment, so as to avoid blind use of medication to cause adverse consequences.