In recent years, the relationship between migraine and epilepsy has attracted widespread attention. According to surveys, 2%-3% of migraineurs have a family history of epilepsy, and 6%-8% of migraineurs have seizures. It has been suggested that childhood migraine can ignite epilepsy, and others have suggested a relationship between migraine and pediatric benign epilepsy. Clinically, migraine has many similarities with certain types of epilepsy, especially autonomic epilepsy, such as both having seizures and both can have aura, nausea, vomiting, headache, and EEG abnormalities. Nevertheless, the pathophysiology and pathogenesis of the two are very different and should be differentiated as follows: 1. 2. Headache epilepsy has an acute onset, mostly temporal and frontal, often bilateral, and is accompanied by other autonomic symptoms. Migraine occurs relatively slowly, with many triggers, typically followed by pulsating throbbing on one side after aura. 3. Both migraine and epilepsy can have EEG abnormalities, but epilepsy is mostly paroxysmal epileptiform discharge waves, such as spike wave and spike-slow wave synthesis. The EEG of intermittent migraine can have focal slow waves and middle temporal spike waves, but they appear on the same side of the headache and often disappear after sleep. This is different from the typical spike waves of epilepsy and appear on the contralateral side of the headache. Migraine has no change or shows a slowed background wave rhythm on the EEG during the attack phase, whereas epilepsy has marked epileptiform discharges.