Patients with celiac disease experience tingling in the limbs, mostly due to peripheral neuritis and sensory disorders complicating celiac disease, which can be relieved by general treatment and medication. 1. General treatment: the onset of celiac disease is mainly due to the patient’s intolerance to gluten (wheat gluten) and lead to chronic autoimmune disease of the small intestine, mainly manifested as chronic diarrhea, abdominal distension and abdominal pain, weight loss, anemia, edema and so on. At present, the main clinical treatment is dietary treatment, lifelong gluten-free diet (avoiding wheat, barley, rye, etc.) is the only treatment method. 2. Drug treatment: patients with severe symptoms need to pay attention to replenish water and electrolytes, maintain acid-base balance; can also use prednisone and other glucocorticoid drugs to improve the patient’s symptoms; at the same time, pay attention to replenish the B vitamins, vitamin D, folic acid, etc., to maintain balanced nutrition. Serious and critical patients can also be given cyclosporine when necessary to improve the absorption function of the patient’s small intestine. Celiac disease patients with tingling limbs are recommended to seek timely medical treatment, and actively receive treatment. Drugs must be taken in strict accordance with the doctor’s instructions, not self-medication, so as not to delay or even aggravate the condition.