There is no advantage or disadvantage to having a gastroscopy with or without anesthesia. Gastroscopy generally includes ordinary gastroscopy (without anesthesia) and painless gastroscopy (anesthesia), both examinations need to be prepared on an empty stomach. Patients need to take local anesthesia medication orally before having a general gastroscopy, which mainly serves to reduce nausea, dry heaving and other discomforts during the examination, but generally speaking, there will still be varying degrees of discomfort, but the cost of a general gastroscopy is relatively inexpensive. Painless gastroscopy requires general anesthesia, during which the patient is in an unconscious state, so there is no obvious nausea, dry heaving and other discomforts. However, there is a certain risk of general anesthesia, and the risk of general anesthesia is correspondingly higher for the elderly and the frail, so painless gastroscopy needs to be accompanied by family members, and the cost of painless gastroscopy is relatively higher. If you have stomach discomfort and other symptoms, it is recommended that you go to the hospital as soon as possible, and have a gastroscopy under the doctor’s evaluation, in order to clearly diagnose and treat the disease, so as to avoid delaying the condition.