Early syphilis is usually treated and symptoms can be relieved within 3~4 weeks, and the serum antibody titer will turn negative within 2~3 years, while the prognosis for advanced syphilis is poor. Syphilis is a sexually transmitted disease caused by the pallid spirochete. It is mainly transmitted through the sexual route, and according to the course of the disease, it is clinically categorized into one, two and three stages of syphilis. Penicillin is preferred for its treatment, and tetracycline, erythromycin, doxycycline, etc. can be chosen for those who are allergic to penicillin. Stage I and II syphilis or early syphilis treatment needs to be once a week, after regular treatment within 3~4 weeks the symptoms can gradually subside. Syphilis needs to be followed up and observed for 2~3 years from the beginning of treatment and regular serologic review, and if there is no recurrence in 2~3 years, it can be judged as clinically cured. On the other hand, stage III syphilis or advanced syphilis causes irreversible damage to tissues and internal organs, and most of the patients will have some effect after treatment, but it is very difficult to realize clinical cure and the prognosis is poor. Therefore, if you are diagnosed with syphilis, please treat it as early as possible and treat it actively. At the same time, please be clean and take protective measures to avoid infection.