There is no so-called “best” medicine or method to relieve prickly heat, but it can be treated by general treatment, topical medicine (glycerine lotion, etc.), oral medicine (loratadine tablets, etc.) and other methods. 1. General treatment: Keep the prickly heat area dry and cool, avoid wearing too much clothing, and try to wear loose and breathable clothing. If itching or pain occurs, ice packs can be used to relieve the symptoms. 2. Topical medication: You can apply glycerine lotion on the itchy area to relieve the symptoms, and if necessary, you can use hydrocortisone cream and other medications under the guidance of a doctor for anti-inflammatory and antipruritic treatment. 3. Oral medication: If there are obvious itching symptoms, you can take oral loratadine tablets, fexofenadine and other antihistamines. If there is an infection, it should be treated with oral antibiotics, such as penicillin or cephalosporins. It is recommended that patients with prickly heat consult a doctor in a timely manner, strictly follow the doctor’s instructions for the appropriate treatment, and avoid the pursuit of the so-called “best use” methods or drugs, in order to avoid the occurrence of serious adverse reactions.