When IgE is higher than 2000IU/ml, the condition is more serious. IgE is immunoglobulin IgE, belongs to one kind of immunoglobulin in the human body, the normal range of normal immunoglobulin IgE is 20~200IU/ml. 2000IU/ml of immunoglobulin IgE is a serious elevation, which can be seen in serious allergic diseases, and can also be seen in multiple myeloma and other diseases. 1. Severe allergic diseases, such as allergic asthma, atopic dermatitis, allergic rhinitis and so on. Severe allergic asthma can lead to severe respiratory distress, which may be life-threatening and requires immediate anti-allergy treatment, such as inhaled glucocorticosteroids like dexamethasone. 2. Abnormal elevation of immunoglobulin IgE can also be seen in multiple myeloma and other diseases, and multiple myeloma belongs to a type of malignant plasma cell disease, which can be accompanied by bone destruction, renal impairment, anemia, decreased white blood cell and platelet counts and other manifestations. It is recommended that the patient should consult a doctor in time, complete the relevant examination to clarify the cause of elevated immunoglobulin IgE, and treat the cause of the disease.