Osteosarcoma can grow anywhere in the bone, except that it is most commonly found in the distal femur, proximal tibia, and proximal humerus. Osteosarcoma is a common malignant bone tumor, common in children and adolescents, and can appear anywhere in the body. In clinical work, the incidence of osteosarcoma is higher in distal femur, proximal tibia, proximal humerus and other bone and joint parts. Osteosarcoma not only destroys the patient’s bone tissue, but also causes calcification in the soft tissue. In the early stage, it is mainly characterized by pain and lumps, etc. The diagnosis can be confirmed by bone CT and pathological tissue biopsy, and targeted treatment plans can be adopted in compliance with the opinions of specialists. Early-stage patients undergo radical surgical resection, with adjuvant radiotherapy after surgery according to the situation. For patients with inoperable osteosarcoma, palliative radiotherapy is available. It is suggested that patients with osteosarcoma should go to regular hospitals regularly, follow the specialist’s diagnosis and treatment advice, standardized treatment and regular follow-up.