Regurgitation and spitting up acid in the night sleep is a manifestation of acid reflux. The causes of acid reflux include mental stress, overwork, improper diet, disease causes, etc. For example, eating spicy and stimulating food, eating too salty, too acidic, too hot food, overeating, gastrointestinal neurosis, esophageal or gastric tumors, acute and chronic gastritis, peptic ulcer, pyloric obstruction, functional dyspepsia, and medication factors leading to gastric acid reflux can cause gastric regurgitation and spitting up in bed. Physiological causes do not need treatment, but need to correct bad habits, pathological causes need to identify the cause and then according to different causes of treatment. Patients who vomit acidic water in the night sleep should actively seek medical treatment, do not self-medication. To use drugs under the guidance of physicians, according to the standard treatment.