Growth hormone deficiency causes short stature generally refers to growth hormone deficiency dwarfism, which can be treated by following the doctor’s instructions to standardize the use of human growth hormone, insulin-like growth factor-1 and so on. 1. Human growth hormone is effective in the clinical treatment of growth hormone deficiency dwarfism. The dosage can be adjusted according to the growth rate and the level of insulin-like growth factor-1. Local and systemic adverse effects of human growth hormone injections are less frequent, but attention should still be paid to the detection of allergy, blood glucose, blood pressure and other related adverse effects. Thyroid function should be monitored during use. 2. Insulin-like growth factor-1 has been used to treat growth hormone insensitivity syndrome in recent years. Early diagnosis and early treatment are more effective. Adverse effects include hypoglycemia. Patients with short stature due to growth hormone deficiency are advised to seek timely medical treatment to avoid delay.