When a tooth undergoes root canal treatment, if there are no uncomfortable symptoms, anti-inflammatory drugs can be withheld. If there is occlusal pain, anti-inflammatory drugs can be taken in moderation to assist in the treatment of inflammation, as follows. 1. No discomfort: Root canal treatment includes root canal preparation, root canal disinfection and root canal filling. Root canal preparation removes the infected materials in the root canal system, and root canal disinfection seals calcium hydroxide and other medicines into the root canals to completely remove microorganisms and toxins left in the root canal system, which basically controls inflammation, and anti-inflammatory medicines may not be taken if there are no discomfort symptoms or mild symptoms. 2. Existence of occlusal pain: If the symptoms of periapical inflammation are serious and occlusal pain still exists after sealing the root canal, anti-inflammatory drugs, such as metronidazole and tinidazole, etc., can be taken to help control the inflammation. Drugs should be used under the guidance of a doctor. It is recommended to visit a hospital to receive professional treatment.