There are many causes of discomfort in the liver area, for example, the most common ones are gallbladder stones cholecystitis, liver abscess, liver cancer, costochondritis, and soft tissue injury in the liver area. If the pain in the liver area is caused by gallbladder stones cholecystitis, it may be combined with pain radiating from the back of the right shoulder in addition to pain in the right upper abdomen. Pain in the right upper abdomen occurs most often when eating fatty foods or when the vagus nerve is excited at night. If gallbladder stones have been diagnosed in the past and the liver pain is preceded by eating, gallbladder stones and cholecystitis are considered to be more likely. Liver abscesses mostly occur in patients with diabetes mellitus, and they are often combined with symptoms such as high fever and chills, while the patient’s mental state is poor. Patients with liver cancer have no pain symptoms in early stage, when liver cancer causes pain in liver area, liver cancer is mostly in middle and late stage, the tumor diameter is larger, and the lump in liver area can be touched by physical examination, and the preliminary diagnosis can be made by auxiliary examination of liver and biliary ultrasound or CT.