Stroke is also known as cerebral stroke. Severe dementia after stroke is mainly caused by damage to brain tissue, which is a pathological manifestation, and can be treated with medication and psychotherapy after the onset of the disease. 1. Drug therapy: patients with brain tissue ischemia, hypoxia, necrosis, which then triggers dementia, amnesia and other manifestations, which need to be combined with the specific circumstances of the use of medication, through the use of memantine, donepezil and other drugs to reduce the patient’s memory loss, dizziness and other discomforts; the use of aspirin antiplatelet aggregation; the use of drugs such as nifedipine to control blood pressure; the use of drugs such as metformin to control glucose and so on. 2. Psychological treatment: the seriousness of severe dementia is serious, and the onset of the patient’s longer, will produce a serious psychological burden. In this case, it is necessary to adjust the state of mind, if necessary, consult a psychiatrist for psychological counseling, to help patients get rid of inner pressure and distress, so as to help the patient’s body and physical and mental health recovery. The cause of severe post-stroke dementia needs to be clarified and treated with medication under the guidance of a doctor, as well as following the relevant principles of therapeutic drugs.