In a small number of patients, kidney damage can occur during the use of omeprazole. Omeprazole is a proton pump inhibitor commonly used in clinical practice, mainly to inhibit the secretion of gastric acid. Most patients do not experience kidney damage during the use of omeprazole. Only a few patients may experience abnormal renal function such as increased creatinine and decreased urine output during the use of omeprazole, which need to be taken seriously. Adverse reactions such as dry mouth, nausea, diarrhea, constipation, and abdominal pain may occur during administration. Severe hepatic and renal insufficiency, allergy to this drug, pregnant women and lactating women need to use this drug with caution. Renal function must be monitored during the use of the drug. In the event of kidney damage during the use of omeprazole, you should go to the hospital as soon as possible, with the doctor to adjust the drug program.