Anterior horn lesions of the spinal cord are a manifestation of poliomyelitis. Poliomyelitis is an acute infectious disease caused by poliovirus. Poliomyelitis virus (poliomyelitisvirus) is a genus of enterovirus in the family of small ribonucleic acid viruses. The virus is observed under the electron microscope as a small, rounded sphere with a diameter of 24-30 nm and a circular particle shape. It contains single-stranded ribonucleic acid, and the nucleic acid content is 20%-30%. The viral nucleoshell consists of 32 capsid particles, each containing four structural proteins, namely VP1 to VP4. VP1 has a special affinity for human cell membrane receptors and is associated with the pathogenicity and virulence of the virus. The prevention of anterior horn lesions of the spinal cord caused by poliomyelitis: 1. autoimmunization The earliest used inactivated polio vaccine (Salk vaccine), the effect of protection of susceptible persons after intramuscular injection is certain, and because it does not contain live vaccine, it is also very safe for immunodeficient persons, some countries also use inactivated vaccine alone to control and almost eliminate poliomyelitis significant effect, but inactivated vaccine caused by the maintenance of immunity is short However, the short duration of immunity caused by the inactivated vaccine is short, repeated injections are required, and it does not cause local immunity, and the preparation price is expensive. Live attenuated vaccine (Sabin vaccine, Oral polio-virus vaccine, OPV) is currently used more often. This live vaccine virus has been passed through tissue culture for many times and has no or very little toxicity to the human nervous system. The immunity of the intestine and pharynx is also enhanced by the production of secretory IgA, which can eliminate the invading wild strains and cut off their spread in the population. Three types of sugar pill vaccine have been made, which can be stored at 2-10℃ for 5 months, 20℃ for 10 days, and 30℃ for 2 days only, so attention should still be paid to refrigeration (4-8℃). 2 months to 7 years old susceptible children are the main target of vaccination. However, children and adults of other ages who are susceptible should also take the vaccine. Large-scale vaccination should be done in winter and spring, and should be given orally in 2 or 3 doses on an empty stomach, not with hot boiled water, so as not to inactivate the virus in the vaccine and lose its effect. 2.Passive immunization Young children who have not taken the vaccine, pregnant women, medical personnel, immunocompromised people, and after local surgery such as tonsil removal, if they are in close contact with the patient, they should be injected with gammaglobulin as early as possible, the dose for children is 0.2~0.5ml/kg, or placental globulin 6~9ml, once a day for 2 days, the immunity can be maintained for 3~6 weeks. 3, isolate patients from the onset of the disease at least 40 days, the first week should emphasize both respiratory and intestinal isolation, excrement to 20% bleach interception and disinfection, food utensils soaked in 0.1% bleach clarification solution or boiling disinfection, or sunlight exposure for two days, the ground with lime water disinfection, contact hands soaked in 0.1% bleach clarification solution, or disinfection with 0.1% peroxyacetic acid, close contact of susceptible The susceptible person should be isolated and observed for 20 days. During the epidemic period, children should go to fewer crowded places, avoid excessive fatigue and cold, and postpone various preventive injections and surgeries that are not urgently needed, so as not to prompt the stroke-type infection to become paralytic.