Human chorionic gonadotropin drops from 112 IU/L to 48 IU/L, and a possible miscarriage of pregnancy is considered. Human chorionic gonadotropin is a glycoprotein secreted by the placenta that can rise as early as 10 days after coitus and peaks throughout pregnancy at about 8 weeks of gestation, decreasing to intermediate levels by the fourth trimester and remaining there until the end of pregnancy. In clinical human chorionic gonadotropin levels are often seen in miscarriage, early pregnancy embryo healthy growth, human chorionic gonadotropin levels will be doubled every other day changes, if there is no doubling of the decline has occurred, consider the possibility of miscarriage of pregnancy. For patients with decreased levels of human chorionic gonadotropin, it is recommended that they consult a regular hospital in a timely manner, improve ultrasound, blood progesterone and other related examinations, under the guidance of a professional doctor to comprehensively assess and analyze, and actively diagnose and treat the condition, so as not to delay the condition.