Coughing chest pain is mainly considered pleurisy, pneumonia and trachea-bronchitis. If there is a bacterial infection, antibiotics can be used to treat it. Commonly used antibiotics include penicillin, cephalosporins, macrolides, quinolones, and so on. If there is no basis for bacterial infection, there is no need to take antibiotic treatment. 1. Pleurisy: mainly manifested as chest pain, cough, chest tightness, shortness of breath, or even dyspnea. Septic pleurisy infection is treated with penicillin such as amoxicillin and other anti-infective treatment, and tuberculous pleurisy is mainly treated with the combination of rifampicin and isoniazid. 2. Pneumonia: different antibiotics are applied according to the main causative organisms, such as Klebsiella infection is mainly treated with aminoglycosides such as streptomycin and gentamicin, and methicillin-resistant Staphylococcus aureus infection is mainly treated with vancomycin. 3. Trachea – bronchitis: according to the different main causative organisms, the application of antibiotics is also different, such as mycoplasma, chlamydia infection is mainly treated with azithromycin or levofloxacin. If caused by Streptococcus pneumoniae, etc., it can be treated with penicillins such as amoxicillin for anti-infection. Cough chest pain may also be caused by other diseases, such as tuberculosis, lung cancer, bronchial dilatation, etc. Symptoms are not relieved or aggravated, it is recommended to consult a doctor in time, to clarify the cause of the disease, and standardize the treatment under the guidance of the doctor.