Symptoms of uveal malignant melanoma with positive isotope 32 phosphorus uptake test. Uveal malignant melanoma is one of the most common malignant intraocular tumors in adults, and its incidence accounts for the first place of intraocular tumors in foreign countries and the second place of intraocular tumors after retinoblastoma in China. This tumor is highly malignant, easily metastasized via blood stream, and is more common in adults, and is easily confused with many fundus diseases in clinical work. Therefore, it should be given full attention in the clinical work of ophthalmology. The disease is more common in middle-aged and older patients. The posterior pole of the eye is the preferred site, and the incidence decreases in the forward direction. What causes uveal malignant melanoma? Abnormal expression of oncogenes and oncogenes leads to cellular malignancy. Uveal melanoma is a highly malignant tumor with no apparent causative agent. Uveal melanoma is a highly malignant tumor that requires early diagnosis. It is important to treat the patient promptly so as to save the patient’s life. Because choroidal melanoma mostly originates from the ciliary nerve, fundus lesions may be combined with pupillary abnormalities (the corresponding pupil is unresponsive, not easily dilated or not square) or fan-shaped hypersensitivity areas in the corresponding parts of the cornea. Scleral inflammation caused by impaired blood flow or localized tumor necrosis may manifest as limited scleral congestion. There is granulation tissue proliferation inside and outside the sclera. Ocular pain. The pain can be caused by secondary glaucoma or tumor necrosis induced uveitis (uveitis or endophthalmitis), or in a few cases, due to tumor infiltration or compression of the ciliary ganglion. Anterior chamber or vitreous hemorrhage is caused by tumor necrosis. Protrusion of the eyeball caused by tumor spreading to the posterior globe. Malignant melanoma of the ciliary body can have different clinical manifestations depending on the site. The anterior aspect of the tumor can easily cause increased intraocular pressure and iris root detachment; the posterior aspect of the tumor can lead to retinal detachment in the periphery, which may only appear clinically similar to central retinopathy or optic papillitis, and is often misdiagnosed or missed if the pupil is not dilated. A mass that progresses from the ciliary body to the central height may compress the lens and cause it to displace or dislocate. In cases of early outward spread, the mass may appear under the anterior bulbar conjunctiva. Intraocular spread of uveal melanoma and spread along the optic nerve is relatively rare, but systemic metastasis along the blood stream is more common. Metastases are most common in the liver, followed by subcutaneous tissue and the lungs, and may also invade the central nervous system. The incidence of metastasis is related to the cell type of the tumor, with epithelioid cell type being the highest and spindle cell type the lowest. If reticulocytes are used as a measure, the higher the reticulocyte content, the lower the metastasis rate; conversely, the lower the reticulocyte content, the higher the metastasis rate.