The epigastric nausea and dry mouth may be caused by chronic gastritis, upper gastrointestinal ulcer, cholecystitis and other diseases, the patient should consult a doctor in time to clarify the cause of the disease. 1. Chronic gastritis: Helicobacter pylori infection and other factors caused by chronic inflammation of the gastric mucosa, the patient will have epigastric discomfort, nausea, dry mouth, fullness, dull pain and other symptoms, you can use omeprazole, bismuth pectin and other drugs for treatment. 2. Upper gastrointestinal ulcers: Ulcers appearing in the digestive tract above the flexor ligament, mostly referring to gastric and duodenal ulcers, patients will have symptoms such as epigastric discomfort, acid reflux, early satiety, nausea, dry mouth, and so on, and can be treated with drugs such as omeprazole and clindamycin under the guidance of doctors. 3. Cholecystitis: If the patient’s epigastric discomfort and nausea and dry mouth occur after eating greasy food, then it should be considered to be caused by cholecystitis, and ursodeoxycholic acid and other drugs can be used for treatment. All of the above drugs should be used under the guidance of a doctor.