The mechanism of action, indications, adverse reactions and contraindications of rabeprazole and domperidone are different, and the differences in the efficacy and use of the two drugs are described below. Domperidone is a gastrointestinal stimulant, peripheral dopamine receptor blocker, directly acting on the gastrointestinal wall, can increase the lower esophageal sphincter tone, prevent gastro-esophageal reflux enhancement of gastric peristalsis, to promote the emptying of the coordination of gastric and duodenal motility, inhibition of nausea, vomiting, and to prevent bile reflux does not affect gastric juice secretion. Domperidone is used for dyspepsia caused by bloating, gastrointestinal reflux, nausea and vomiting caused by functional or organic, etc. Gastrointestinal obstruction, moderate-to-severe hepatic insufficiency, gastrointestinal hemorrhage and other patients are contraindicated, occasional dry mouth, diarrhea, nausea, allergies and other adverse reactions. Rabeprazole is through the inhibition of gastric wall cell enzyme system and block gastric acid secretion, reduce gastric mucosal irritation relief of peptic ulcer, reflux esophagitis, etc. caused by acid reflux, pain, acute bleeding symptoms. Rabeprazole is used for the treatment of duodenal ulcer, gastro-esophageal reflux disease, Helicobacter pylori infection, etc. It is contraindicated in patients with a history of drug allergy to the ingredients of this drug, and is contraindicated in patients who are taking atazanavir sulphate, which may cause shock, granulocyte deficiency and other adverse reactions. The above drugs need to be used under the guidance of doctors in regular hospitals, do not use drugs privately to avoid causing adverse effects. If there is any discomfort, you should consult a doctor promptly.