Sotossyndrome, or cerebralgigantism, cerebralgigantismsyndromeinchildhood, also known as childhood giant brain syndrome ( macrencephalysyndrome, Sotos syndrome, is a syndrome in infants and school-age children with rapid skeletal growth, huge head and delayed intellectual development. The syndrome is characterized clinically by significant growth of the body in the neonatal period, long head and giant brain, mental retardation, specific facial features and abnormal limb morphology. The etiology of this syndrome is unknown. It may be caused by pathological factors in utero or by impairment of hypothalamic-pituitary axis function. It is believed that the disease is familial and dominantly inherited, with a higher incidence in males than in females (4:1 or 3:1), so it is usually considered as X-linked inheritance. In 1973, Butenandi pointed out that the disease may be caused by hyper-responsiveness of peripheral tissues to growth hormone. This syndrome is similar to Lawrence-Seip syndrome and Russell syndrome, so the three syndromes may be part of the same syndrome. The syndrome is clinically characterized by significant growth in the neonatal period, long head and giant brain, mental retardation, specific facial features and abnormal limb morphology. The birth weight and length of the child are greater than normal, and the growth is rapid during the first 4-5 years of life, and then the growth seems to approach normal and stable, but the measured value is still more than two standard deviations from the mean value at the same age. The child may have a giant skull, long head, distant eye spacing, congenital dullness, peculiar facial features, prominent jaw, high palatal arch, mental retardation, clumsy movements or ataxia. Sometimes there may be obesity, twitching, abnormal hand skin pattern (increased number of total finger ridges between triangle a-b, large interfoveal lines and fingerprints with bucket-shaped lines are common), but abnormal skin texture has also been reported. The diagnosis was confirmed based on the clinical features of the presentation and laboratory and ancillary tests, and a positive family history facilitated the diagnosis of the disorder.