Renal puncture biopsy is an invasive test. Generally, acute glomerulonephritis does not require renal puncture biopsy, and can be clinically diagnosed based on clinical manifestations and serum complement C3 level. When clinical diagnosis is difficult, renal puncture biopsy can be considered to clarify the diagnosis. Acute glomerulonephritis syndrome (manifestations of glomerulonephritic hematuria, proteinuria, and transient edema) occurring 1 ~ 3 weeks after streptococcal infection with a transient decrease in serum C3 is clinically diagnostic for acute glomerulonephritis. Those with oliguria for more than 1 week or progressive decrease in urine output with deterioration of renal function, those with a disease duration of more than 2 months without a tendency to improve, and those with acute nephritis syndrome with nephrotic syndrome should have timely nephron puncture biopsy for definitive diagnosis and targeted treatment. Acute glomerulonephritis, it is recommended that patients go to the relevant departments of the hospital in a timely manner, under the guidance of a professional doctor, improve the relevant examination, so as to clarify the diagnosis of the disease, and receive standardized treatment.