Pneumonia is likely to work with amoxicillin if it is caused by a bacterial infection. If it is caused by other reasons, such as mycoplasma, viruses and other pathogenic microbial infections, amoxicillin can not be effective. Some drugs, autoimmune diseases, or long-term exposure to radiation and other non-infectious factors can also lead to pneumonia, which can not be effective with amoxicillin. Oral amoxicillin is generally less effective than intravenous amoxicillin in pneumonia. The effect is only possible if the corresponding bacteria are sensitive to amoxicillin. But if it is not sensitive, amoxicillin will not be effective. In the case of more pronounced pneumonia, hospitalization is recommended for treatment with fluids. The effectiveness of antibiotics can only be determined by clinical experience at the beginning, so it is best to take a bacterial culture before applying antibiotics, and the specimen can be either sputum or blood. After applying antibiotics for a period of time, if the corresponding effect is not good, you can choose sensitive antibiotics according to the results of drug sensitivity test.