Hormonal creams include estrogens and glucocorticoids, with glucocorticoids being the most common. Their main side effects and hazards include local skin side effects such as thinning of the dermis and epidermis, hyperpigmentation or hypopigmentation, secondary infections, and dependence. Glucocorticoids have strong anti-inflammatory, anti-allergic and anti-itch effects. They are commonly used in the treatment of allergic diseases and immunologic diseases. Long-term use of patients will have local skin, such as epidermal and dermal thinning, hyperpigmentation and subcutaneous capillary dilatation, etc.; secondary to other bacterial and fungal infections; some patients discontinue the drug after the symptoms may reappear and other side effects. It should be noted that patients with fungal-induced ringworm and tinea pedis, and patients with localized ulcers should disable hormonal ointments to avoid aggravation of the skin lesions. Patients who need to use hormone ointment are advised to consult a doctor and follow the doctor’s instructions, so as not to cause adverse reactions.