Cough with sputum may be caused by acute upper respiratory tract infection, pneumonia, chronic obstructive pulmonary disease, bronchial dilatation, etc., need to take medication according to the cause. 1. Acute upper respiratory tract infection: If the cough with sputum is caused by acute upper respiratory tract infection, you can use antibiotics such as cefuroxime, combined with dextromethorphan, pentoxyverine and other cough suppressants, as well as acetylcysteine, bromhexine hydrochloride and other expectorants under the guidance of the doctor. 2. Pneumonia: If the cough with sputum is caused by pneumonia, it is necessary to check the pathogen. For pneumonia caused by Streptococcus pneumoniae, antibiotics such as amoxicillin clavulanate potassium and cefixime are used under the guidance of a doctor. If it is Mycoplasma pneumoniae pneumonia, you need to follow the doctor’s instructions with azithromycin, erythromycin and other antibiotics. 3. Chronic Obstructive Pulmonary Disease (COPD): For coughing and phlegm caused by COPD, you can use antibiotics such as amoxicillin and levofloxacin as prescribed by your doctor. In addition, you can also give the patient under the guidance of the doctor with aminoglutethimide hydrochloride, hydroxymethylstein and other expectorants. 4. Bronchodilatation: If the cough is caused by bronchodilatation with phlegm, then you need to use bromhexine hydrochloride, aminobromine hydrochloride and other expectorants, as well as compound methoxynamine, codeine and other cough suppressants. Antibiotics such as levofloxacin and ceftazidime are recommended for those with co-infections. Cough with phlegm may also be caused by pharyngitis, bronchial asthma, acute bronchitis, lung cancer and other diseases. It is recommended that patients with cough with sputum need to consult a doctor in a timely manner, you can follow the doctor’s instructions to choose the appropriate measures for treatment.