Azithromycin is generally ineffective in treating colds and sore throats caused by viral infections, but can be effective in treating colds combined with bacterial infections. Azithromycin is a macrolide antibiotic that can be used to treat infections caused by sensitive bacteria, but is not effective for sore throats caused by viral infections. If the sore throat is caused by a cold combined with a bacterial infection, and the causative organism is sensitive to azithromycin, then the application of azithromycin can play a certain therapeutic effect. In addition, it should be noted that the use of azithromycin may cause abdominal pain, diarrhea, nausea, vomiting, etc.; allergic to the drug need to be prohibited; impaired liver function need to be careful with azithromycin. Cold and sore throat patients can not abuse drugs, medication should follow the doctor’s instructions, follow the principle of rational scientific use of drugs.