The main reason for chest tightness when eating betel nut is that betel nut contains betel nutine, which has some hormonal functions similar to those of excitatory cholinergic receptors in the body. It can cause the body’s glandular secretion, the inflammatory material of the bronchial mucosa to exude, and can lead to the contraction and spasm of the bronchial smooth muscle. This leads to narrowing of the airway, resulting in ventilation and air exchange dysfunction, and chest tightness. At this time, care should be taken not to continue eating betel nut. Drugs to relieve bronchoconstriction, such as salbutamol nebulizer, terbutaline nebulizer, ipratropium bromide nebulizer, etc., can be given appropriately, and nebulized inhalation therapy can be performed. Appropriate intravenous drip of energy combination, glucose saline can also be given to dilute phlegm and promote phlegm discharge to prevent airway blockage, which can relieve the symptoms of chest tightness.