Blistering on the lips on fire is usually caused by mental factors, and generally appears to be in a poor state due to abnormal mental sensations, when it is easy to have a low body immunity, which can easily induce an outbreak of herpes simplex virus, it is easy to have blistering on the lips on fire, which requires antiviral treatment. Alternatively, it may be due to the presence of ulcers, which patients generally consider themselves to be blisters on the mouth, and which are usually caused by vitamin and micronutrient deficiencies. It can also be caused by systemic diseases, such as gastrointestinal diseases or a history of major tumors or radiotherapy, which can cause ulcerative symptoms, which are usually painful. It is usually recommended to improve the body’s immune system, for example, using drugs such as levamisole or transfer factor, which can improve the body’s resistance.