The pain in the upper middle abdomen when pressed may be due to gallbladder stones, pancreatitis, duodenal ulcer and other causes. 1. Gallbladder stones: When the cholesterol and bile acid phospholipid concentration ratio changes, as well as bile sludge and other factors can lead to gallbladder stones. When the gallbladder contracts after a full meal and eating greasy food, it may be painful to press in the middle and upper abdomen. 2. Pancreatitis: When the outflow of pancreatic juice is blocked, digestive enzymes are activated in the pancreas causing irreversible changes in pancreatic cells and inflammation. Pressure pain in the upper and middle abdomen may occur after a full meal and alcohol consumption. 3. Duodenal ulcer: the mucous membrane of the duodenum is damaged under the action of some digestive enzymes, and an ulcer is formed. Often appear in the meal before the middle and upper abdomen pressure pain. If you have pain in the upper and middle abdomen, it is recommended that you consult a doctor for further examination and clarification of the cause with the help of the doctor and targeted treatment or therapy.