Skin biopsy can detect skin tumor lesions, herpetic dermatosis, infectious dermatosis and other skin lesions that have not been diagnosed clearly. 1. Skin tumor lesions: skin biopsy is the gold standard for skin tumor lesions, i.e. skin tumors must be diagnosed through pathology. When patients have undiagnosed moles, warts, suspicious skin tumor lesions (such as Bowen’s disease, squamous cell carcinoma, basal cell carcinoma, malignant melanoma, etc.), a small amount of tissue from the lesion can be taken by cutting, drilling or excision method for pathological examination, which can help to clarify the nature of lesions and guide the treatment. 2. Herpetic dermatosis: when the skin appears the blisters of unknown reason, herpetic lesion, can take a small amount of blister peripheral tissue for skin biopsy, help to clarify the nature of the lesion, in addition can take the blister wall, blister fluid tissue for biochemical, bacteriological examination, help to further clarify the cause of the disease, which is for the diagnosis of pemphigus, pemphigus-like disease, differential diagnosis, treatment is of great significance. 3. Infectious skin diseases: skin biopsy can also be used in infectious skin diseases, such as certain viral skin diseases will have certain specific changes, some deep fungal disease, leprosy can be found through the skin biopsy of the relevant pathogens, thus helping to diagnose some infectious skin diseases. It should be noted that skin biopsy is an invasive operation, and it is recommended that patients go to regular hospitals and have this operation performed by specialized doctors.