Wandering pain usually refers to the pain in several joints of the whole body. Rheumatoid arthritis wandering pain is mainly related to the etiology of rheumatoid arthritis, the disease is related to genetics, infection, the environment and other factors, and its basic pathological changes is synovitis, can attack the whole body of multiple joints, symmetric joints are mainly, easy to appear wandering pain. Rheumatoid arthritis is a chronic, systemic autoimmune disease with erosive, symmetric polyarthritis as the main clinical manifestation. The exact pathogenesis is unknown. The basic pathologic changes are chronic inflammation of the synovium, formation of vascular cataracts, and progressive destruction of articular cartilage and bone, ultimately leading to joint deformity and loss of function. This disease is the result of a combination of genetic, infectious and environmental factors. Its basic pathological change is synovitis, which can involve several joints throughout the body, such as the metacarpophalangeal joints, interphalangeal joints, wrist joints, and other joints with wandering pain, and therefore will be manifested as wandering pain in the joints. The main manifestation of rheumatoid arthritis patients is stiffness, pain and swelling of several joints such as metacarpophalangeal joints, interphalangeal joints and wrist joints, which will gradually worsen with the passage of time, and can also involve several systems of the whole body such as the lungs, the heart, the nerves and blood vessels. Therefore, early detection, early diagnosis and early treatment are particularly important. Rheumatoid arthritis patients are advised to go to the hospital in time and follow the doctor’s instructions for standardized diagnosis and treatment.