Estrogen sequential therapy is the application of tonic and progesterone pills, which are used continuously to make the endometrium appear to shed periodically and return the menstrual cycle to a normal state. The following diseases need to be excluded before treatment with this method: 1. Uterine fibroids should not be treated with this method. 2. Breast enlargement is also not recommended to be treated with this method. 3. Patients with thrombotic tendency should also not be given treatment with this method. If you have any of the above mentioned diseases, you can use other methods to give the appropriate treatment. In addition, contraceptive measures should be taken during the course of estrogen and progestin sequential therapy.