Perianal eczema is one of the common diseases in dermatology, and medications used to treat perianal eczema dermatitis include antihistamines, glucocorticosteroids, and antibiotics. Perianal eczema is a common inflammatory disease that occurs in the skin around the anus and is a type of eczema. 1. Antihistamines:Perianal eczema will appear around the anus skin intense itching discomfort, accompanied by local oozing, cracking or erosion. Oral antihistamines can be taken for treatment, common drugs are cetirizine, loratadine and so on. Common adverse reactions include dizziness, drowsiness and fatigue. 2. Glucocorticoid drugs: topical glucocorticoid creams such as Dinaid cream, mometasone furoate cream, etc. have good anti-itch and anti-inflammatory effects, suitable for the treatment of subacute or chronic perianal eczema. 3. Antimicrobial drugs: acute perianal eczema caused by secondary infection, this time the use of antibiotics for treatment. Common drugs are amoxicillin, azithromycin, metronidazole, etc., common adverse reactions are allergies, nausea, vomiting, loss of appetite, etc., allergic to the ingredients are prohibited. Perianal eczema dermatitis in different cases with different medications, do not take medication without authorization, it is recommended to consult a doctor in a timely manner, so as not to delay the condition.