Submucosal elevation of the ascending colon with ulcerative bleeding may be associated with infectious enteritis, inflammatory bowel disease, intestinal malignant tumors and other causes, need to be diagnosed according to pathological findings, can be prescribed anti-infective drugs, aminosalicylic acid drugs, glucocorticosteroids and other medications and surgical treatment. 1. Infectious colitis: it is due to the specific inflammatory changes in the intestinal tract caused by bacteria, fungi, viruses, etc., and there can be ulcers and bleeding in the submucosa of the colon, and the treatment needs to be anti-infective treatment for the pathogens. 2. Inflammatory bowel disease: refers to the intestinal non-specific inflammation of unknown cause, including ulcerative colitis and Crohn’s disease, the treatment can follow the doctor’s instructions to take aminosalicylic acid drugs, glucocorticoids, immunosuppressants, etc., if necessary, endoscopic or surgical treatment. 3. Intestinal malignant tumors: malignant tumors of the ascending colon, if the pathology is clear, timely surgery, chemotherapy and other treatments are recommended. There are many other reasons for bleeding ulcers under the submucosa of the ascending colon, and it is recommended to take targeted treatment after diagnosis, so as not to delay the condition.