At present, for high-sensitivity C-reactive protein measurement machine is different, its reference value is also different, most of the current regulations are <2.5mg/dL, such a value belongs to the normal. The clinical significance of high-sensitivity C-reactive protein is very great, it mainly reflects acute and chronic inflammatory diseases such as tissue injury, infection, tumor, myocardial infarction. In some inflammatory diseases, such as rheumatoid arthritis, vasculitis, and gout, C-reactive protein is also elevated. Therefore, if there is an elevation of high-sensitivity C-reactive protein, we should look for the cause of the problem, in the end, it must be combined with some other manifestations of the patient, considering which organ or which tissue may have a problem, and then the abnormal elevation of high-sensitivity C-reactive protein can be highly suspected, in fact, it is just an indicator to assist in the diagnosis.