Leg pain at night can be relieved by the following treatments: first, oral pain medication, such as meloxicam, celecoxib, lorsoprofen sodium tablets, or oral aminoglutethimide tablets to relieve pain. Second, to identify the cause, according to different causes to carry out different treatments: 1, if it is caused by cold, to get out of the cold environment, pay attention to leg warmth, can effectively relieve pain. 2, if it is due to lumbar spine disease, such as lumbar disc herniation or lumbar vertebrae instability caused by leg pain, to carry out the relevant examination, early lumbar spine braking and rest, oral medication, surgery if necessary. 3, if it is due to lumbar spine disease, such as lumbar disc herniation or lumbar vertebrae instability caused leg pain. If the pain is caused by lumbar spine tumor or tuberculosis compressing the nerves, early anti-tuberculosis and surgical treatment of the tumor should be carried out.4. If the pain is caused by lumbar spinal stenosis compressing the nerve roots, oral nerve nutritive medication should be carried out, and the serious cases will need surgical treatment.