Diffuse liver changes can be seen in viral hepatitis, cirrhosis, drug-induced liver damage, and so on. 1. Viral hepatitis: Diffuse liver changes refer to a manifestation of the liver tissue itself in imaging. When chronic hepatitis occurs, the hepatitis B virus causes a certain degree of damage to liver cells, and the cells of the liver form diffuse lesions in the process of self-repair. 2. Cirrhosis: patients with cirrhosis are mostly transformed from chronic liver damage, and fibrosis will also manifest as diffuse liver lesions. 3. Pharmacologic liver damage: The use of drugs that are damaging to the liver may lead to diffuse changes in the liver, requiring a detailed history. Even if diffuse liver changes occur, if the liver function can be compensated, the test results may be normal or partially normal. It is recommended to consult with a regular hospital to improve other tests and make a clear diagnosis.