If you want to quickly recover the sense of unreality, the main thing is to actively medication, if one’s sense of unreality is caused by severe depression, you can consider the use of selective 5-hydroxytryptamine reuptake inhibitors, such as fluoxetine, sertraline, paroxetine, fluvoxamine and other drugs, but also duloxetine, venlafaxine and other dual-channel drugs, which are very effective in treatment. If the feeling of unreality is caused by severe schizophrenia, you should consider using antipsychotic drugs, such as the new antipsychotic drugs such as risperidone, olanzapine, ziprasidone, aripiprazole, etc., which are very effective and have fewer side effects. The above medication is more critical, but no matter which medication is used, it should be analyzed on a case-by-case basis.