Pus from a broken pimple can be sterilized using iodophor and topical antibiotics can be applied to promote the inflammation to subside. The pimple broke pus suggests the occurrence of infection, patients are advised to avoid touching the pimple with their hands, and need to use iodophor to disinfect the local skin and remove the pus on the surface. After the pus is removed, you can apply mupirocin ointment and erythromycin ointment locally to control the inflammation. If necessary, oral antibiotics such as ceftazidime can be taken to improve the symptoms. Due to individual variability, there is no absolute most effective and safest drug, need to be standardized use under the guidance of the doctor.