Vaccination does not prevent AIDS, and a vaccine against AIDS has not yet been successfully developed and is not yet available for clinical use. AIDS is a chronic infectious disease caused by human immunodeficiency virus infection, which can destroy the body’s immune system and eventually lead to a variety of opportunistic infections and the occurrence of tumors. It is still the difficulty and focus of clinical treatment, so the prevention of AIDS is very important. First of all, the mode of transmission of AIDS should be clarified in order to do a better job of prevention. AIDS comes from unclean sexual contact, so it is necessary to standardize the treatment of sexually transmitted diseases and avoid unclean sexual contact, especially homosexuality may increase the way of AIDS transmission. Secondly, care should be taken to avoid exposure to blood and body fluids, such as irregular blood donations and blood transfusions. Since a vaccine for AIDS has still not been developed, there is no vaccine to prevent the transmission of AIDS.