Osteosarcoma is usually not treated with oral drugs, and the clinical treatments include chemotherapy, surgery, radiotherapy and so on. 1. Chemotherapy: patients with osteosarcoma usually don’t need oral drugs for treatment, and can be treated with neoadjuvant chemotherapy through methotrexate, vincristine and other drugs, which can effectively improve the prognosis of non-metastatic osteosarcoma. 2. Surgical treatment: there are two main surgical methods in clinic, one is to keep the limbs of patients, which is usually applied to patients with limited lesions of osteosarcoma, and can ensure the quality of life of patients to the greatest extent. The other one is amputation surgery, which is usually applied to patients with extensive invasion of osteosarcoma. 3. Radiotherapy: it is usually applied to patients whose lesions cannot be completely removed by surgery or who are not suitable for surgery. Chemotherapy for osteosarcoma is not a routine treatment plan, and the combined treatment of radiotherapy and chemotherapy can be considered to control the progress of osteosarcoma. Clinical treatment of osteosarcoma patients usually combines a variety of treatment options, patients should not take drugs privately, so as not to cause physical damage.