After lupus nephritis develops into uremia, patients may experience discomfort such as edema and usually need renal replacement therapy, which can affect their daily life as well as the quality of survival. Uremia means end-stage renal failure, irreversible renal impairment, and lupus nephritis belongs to one of the common causes of end-stage renal failure; patients with end-stage may experience a variety of clinical symptoms, such as intractable edema, fatigue, chest tightness, decreased diet, nausea, and so on. Due to irreversible damage of renal function, patients with lupus nephritis uremia usually need to rely on renal replacement therapy, such as hemodialysis, peritoneal dialysis, etc. for a long period of time, which causes psychological, financial, physical and other pressures and pains to the patients. The daily life of patients is usually significantly affected, and they need to adjust their dietary structure, limit the intake of salt, water, potassium, protein and other substances, and at the same time, avoid the use of nephrotoxic drugs, pay attention to rest, avoid exertion, and so on. It is recommended that patients must visit regular hospitals and take active treatment under the guidance of physicians, so as to control the development of the disease as much as possible, improve the quality of life and prolong the life span.