Under normal circumstances, CA125 will not be elevated when menstruation is approaching, CA125 elevation for gynecology may have the following reasons: 1. Ovarian tumors can cause CA125 to increase and are malignant tumors. 2. Endometriosis, such as adenomyosis or other parts of the endometriosis foci, can also cause CA125 elevation, but it is a mild increase, and will not be obvious changes in the follow-up examination. However, it is mildly elevated and does not change significantly on retesting, and the diagnosis is basically made by combining it with the clinical history. In addition, there are some conditions that may cause CA125 to increase, such as taking certain drugs may cause CA125 to increase, and it is recommended to review regularly, such as lung tumors may also cause CA125 to increase. In the event of an increase in CA125, it is important to investigate the cause in conjunction with the clinical history.