Severe brain injuries including stroke and traumatic brain injury lead to tetraplegia, swallowing and speech disorders, and impaired consciousness. Most patients need tracheotomy to maintain an open airway due to restricted breathing and coughing functions, and patients face many difficulties in post-emergency rehabilitation. Due to inappropriate early rehabilitation interventions, patients spend a long time in intensive care, unable to get off the ventilator, recurrent infections, limb muscle atrophy, severe disuse syndrome, and high treatment costs. These patients with severe neurological injury need early intervention of comprehensive rehabilitation, including respiratory rehabilitation, cerebral function rehabilitation, motor rehabilitation, and swallowing and speech rehabilitation, to promote patients’ early discharge from bed as soon as possible, reduce complications, lower medical costs, and improve quality of life.