Ventricular remodeling refers to the changes in the original material and structure of the heart as a result of various forms of injury, and is an adaptive response of the organism to injury. Various primary myocardial injuries and overloading of the heart will impair the heart’s function, and then the body’s compensatory mechanism will be activated to change the material structure of the heart muscle, such as enlarging the ventricles or thickening the walls of the heart in order to satisfy the normal blood supply of the body. However, if the myocardium is persistently damaged, it may exceed the body’s own compensatory function, thus causing the symptoms of heart failure. The pathogenesis of ventricular remodeling is complex and involves the nervous system and endocrine system. Once ventricular remodeling occurs, it rarely returns to normal and requires a program to reverse the remodeling depending on the cause, such as reperfusion therapy or medications such as nitroglycerin to mitigate further myocardial damage and remodeling. Once ventricular remodeling has been detected, it is important to follow your doctor’s instructions for proper treatment. Do not leave it unattended to avoid further progression of the condition or even eventual heart failure.