Decrease in HDL cholesterol is often related to physiological factors, coronary heart disease, diabetes, etc., and needs to be improved according to the cause of the disease, such as lifestyle improvement and drug treatment. 1. Physiological factors: often related to smoking, low exercise, need to do some improvements in daily life and habits, adhere to exercise, stop smoking. 2. Coronary heart disease: when coronary artery stenosis occurs, it may lead to a drop in HDL cholesterol, which needs to be treated as soon as possible, such as choosing sublingual nitroglycerin, isosorbide nitrate, or interventional therapy. 3. Diabetes mellitus: HDL cholesterol decreases when blood glucose levels remain high. Oral hypoglycemic drugs, such as metformin, gliclazide and glipizide, should be taken as soon as possible after diabetes is detected. If the HDL cholesterol is found to be significantly decreased, you should consult a doctor in time to clarify the cause of the disease and then use the appropriate medication.